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Understanding MS
 
 
MS Practice Profiles: Cognitive Dysfunction in MS  


Several disturbances in thought processes occur in persons with MS, including slowed cognition, impaired concentration and memory, loss of complex language, and impaired problem solving and decision-making capacity. There is no simple tool available to assess subtle cognitive losses in primary care settings.

Robert J. Fox, MD (Program Chair)
Nilay Shah, MD
Jeffrey A. Wilken, PhD


 
MS Practice Profiles:
Relapsing-Remitting MS Changing to Progressing MS
  


The clinician treating a patient who has moved from relapsing-remitting MS to the progressing form of the disease faces difficult management decisions. This case-based program will explore expert opinions on available treatment options and follow up care in this challenging situation.

Robert J. Fox, MD (Program Chair)
Nilay Shah, MD


 
MS Practice Profiles:
Clinical-Pathological Disconnect
  


This case-based presentation will look at the clinical challenges of a patient who presents in disease remission but who has a progressively worsening picture on MRI.

Robert J. Fox, MD (Program Chair)
Nilay Shah, MD
(Program Chair)
J. Theodore Phillips, MD, PhD


 
MS Practice Profiles:
Therapeutic Choices in Progressing Disease
  


The benefits of interferon-beta therapy have been shown to be greater in clinically isolated syndromes and relapsing-remitting MS than in secondary progressive MS.

Robert J. Fox, MD (Program Chair)
Nilay Shah, MD
(Program Chair)
Randall T. Schapiro, MD


How do you manage patients that report paralyzing symptoms in one or both legs post injection of interferon (beta-1a)? Should these patients continue therapy or are there any medications that can be given to prevent or manage this reaction?
Two different post-interferon injection syndromes seem to account for most of these events: First, even relatively small increases in core body temperature post-injection can result in temporary, but reversible leg muscle weakness. The pathophysiology of this seems to be closely related to the well-known Uhthoff's phenomenon.
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