For more MS programs visit MSLeaders.org, which is not associated with Johns Hopkins

Important Drug Alert: Voluntary suspension in the distribution and marketing of Tysabri® (natalizumab). Physicians should suspend dosing of TYSABRI until further notification. For more information, click here.
The Implications of Natalizumab for Multiple Sclerosis (MS) Therapy
Jointly sponsored by the Johns Hopkins University School of Medicine, the Institute for Johns Hopkins Nursing, and the University of Tennessee College of Pharmacy.
QUICKLINKS >> Program Overview
CME/CE Information
Faculty
Faculty Disclosures
Off-Label Discussion
Launch Presentation

Program Overview
The approval of natalizumab for the treatment of MS presents MS-treating physicians and nurses with another therapy in their MS armamentarium. Recently released data from the Phase III natalizumab AFFIRM trial demonstrates a reduction in the risk of exacerbation by 66% in the first year of therapy, presenting a significant improvement over current MS therapies. This educational activity presents the natalizumab Phase III data and provides an expert discussion and Q&A about the implications natalizumab may have for the treatment of MS, including infusion therapy and indications for use, alone and in combination with existing disease modifying therapies.

Program Format
An Internet-based, CME/CE-accredited professional education program.

Target Audience
This program has been developed for MS-treating physicians, nurses, and pharmacists. There are no prerequisites to participate in this activity.

Learning Objectives
Following this program, the participant should be able to:

  • Describe the mechanisms of action of immunotherapies in multiple sclerosis
  • Integrate infusion therapies into the treatment of patients with multiple sclerosis
  • Interpret the results of natalizumab clinical trials and the implications for individual patients
  • Explain the roles of mono- and combination therapies in multiple sclerosis

Disclaimer
The opinions and recommendations expressed by faculty and other experts, whose input is included in this program, are their own. This enduring material is produced for educational purposes only. Uses of the Johns Hopkins University School of Medicine and the Institute for Johns Hopkins Nursing names imply review of educational format design and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

CME/CE Information

Accreditation
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The Johns Hopkins University School of Medicine, The Institute for Johns Hopkins Nursing, and the University of Tennessee College of Pharmacy.

Physicians: The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

Nurses: The Institute for Johns Hopkins Nursing is accredited as a provider of continuing education in nursing by the American Nurses Credentialing Center Commission on Accreditation.

Credit Designation
Physicians: The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 1 category 1 credit(s) toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

Nurses: The Institute for Johns Hopkins Nursing designates this activity for a maximum of 1.2 contact hours. Claim only those contact hours actually spent in the activity.

Pharmacists: This program is approved for one (1) hour credit (0.1 CEUs) and is co-sponsored by the University of Tennessee College of Pharmacy who is approved by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmaceutical education. Program #: 064-999-05-250-H01. Grievance Policy

A participant, sponsor, faculty member or other individual wanting to file a grievance with respect to any aspect of a program sponsored or co-sponsored by the UTCOP may contact the Associate Dean for Continuing Education in writing. The grievance will be reviewed and a response will be returned within 45 days of receiving the written statement. If not satisfied, an appeal to the Dean of the College of Pharmacy can be made for a second level of review. Date of Release and Expiration
Physicians and Nurses: This course was released on January 18, 2005 and will expire on January 18, 2006. Credit cannot be awarded after this date. Estimated time to complete this educational activity: 1 hour.
Pharmacists: Credit cannot be awarded after February 2008. Estimated time to complete this educational activity: 1 hour.

Responsibility Statement
The Johns Hopkins University School of Medicine, The Institute for Johns Hopkins Nursing, and The University of Tennessee College of Pharmacy take responsibility for the content, quality and scientific integrity of this CME/CE activity.

Privacy Statement
The Johns Hopkins University School of Medicine (JHUSOM) and The Institute for Johns Hopkins Nursing (IJHN) are committed to protect the privacy of our participants. We maintain our Internet site as an information resource and service for health professionals. The Johns Hopkins University School of Medicine and The Institute for Johns Hopkins Nursing will keep your personal information confidential when you participate in an Internet based program. Your information will never be given to anyone outside of the JHUSOM and IJHN continuing education programs. The Johns Hopkins University School of Medicine and The Institute for Johns Hopkins Nursing collect only the information necessary to provide you with the services that you request.

Faculty

Douglas A. Kerr, MD, PhD (Course Director)
Assistant Professor of Neurology
Johns Hopkins University School of Medicine

Douglas A. Kerr, MD, PhD is an assistant professor of neurology with a joint appointment in the department of molecular microbiology and immunology. He specializes in transverse myelitis and multiple sclerosis. Dr. Kerr has established the Johns Hopkins Transverse Myelitis Center, which is the only such center in the entire world. The center utilizes the expertise of physicians and therapists from a variety of disciplines including neurology, neurosurgery, neuroradiology, rheumatology, rehabilitation medicine and urology for a comprehensive evaluation of transverse myelitis.

Dr. Kerr also has research interest in determining the cause(s) of transverse myelitis, evaluating novel markers to help prognosticate outcomes in the acute phase, and in developing novel treatments. Dr. Kerr also investigates neural stem cells as a potential tool for functional recovery in patients with transverse myelitis and motor neuron disease. He has made significant discoveries concerning the basic molecular biology of neuronal apoptosis, especially in motor neurons of the spinal cord.

J. Theodore Phillips, MD, PhD (Moderator)
Clinical Associate Professor of Neurology
University of Texas Southwestern Medical Center

J. Theodore Phillips, MD, is the director of the Multiple Sclerosis Center at Texas Neurology in Dallas. He serves as a clinical associate professor of neurology at the University of Texas Southwestern Medical Center and as an attending neurologist at Baylor University Medical Center in Dallas.

Dr. Phillips is a graduate of the University of Texas at Austin with special honors in chemistry, and received his MD and his PhD in immunology, and neurology residency training from the University of Texas Southwestern Medical Center at Dallas.

He is a principal developer of a national registry for MS (MSTRAC) and is a principal investigator in several ongoing clinical treatment trials in MS.

Shirley O'Leary, RN, MSCN
Multiple Sclerosis Center
Texas Neurology

Shirley O'Leary, RN, MSCN, practices with J. Theodore Phillips, MD, at the Multiple Sclerosis Center at Texas Neurology. Over the last 10 years she has been involved in all aspects of patient care, including MS research. She is a member of the International Organization of MS Nurses and the American Association of Neuroscience Nurses and has collaborated on several published MS articles.

Julie Farace, RN, BSN
The Johns Hopkins Hospital

Julie Farace, RN, BSN, CNRN is on staff at The Johns Hopkins Hospital in the Department of Radiology. She has worked for The Johns Hopkins Transverse Myelitis and Multiple Sclerosis Centers, and she comes from a strong background in neurosciences that ranges from critical care to the outpatient setting. Her background also includes experience coordinating research studies for MS and TM under the direction of Dr. Douglas Kerr. She is a member of the American Association of Neuroscience Nursing.

Frederick E. Munschauer, MD
Professor of Clinical Neurology and Internal Medicine
University at Buffalo School of Medicine and Biomedical Sciences

Frederick E. Munschauer, MD, is a board-certified specialist in neurology and internal medicine with a subspecialty in critical care. He is a professor of clinical neurology and internal medicine at the State University of New York at Buffalo School of Medicine and Biomedical Sciences and serves as interim chairman of the department of neurology, as well as acting chief of The Jacobs Neurological Institute of Kaleida Health, Buffalo, New York.

Dr. Munschauer received his medical degree from McGill University, Montreal, Quebec, Canada, and completed an internship and residency in internal medicine and a residency in neurology at The Johns Hopkins Hospital, Maryland, USA. He also completed a fellowship in neurological and neurosurgical intensive care at The National Hospital for Nervous Disease, London, UK. Dr. Munschauer is a member of the American Academy of Neurology, the American Heart Association, the American Medical Association, the American Society of Neuroimaging, and the Society of Critical Care Medicine.

Dr. Munschauer has researched extensively in the use of interferon-b1a (IFN-b1a) as treatment for relapsing-remitting multiple sclerosis (MS) and was coinvestigator of phase III clinical trials and the CHAMPS study. His publications include the phase III clinical trial results, as well as the rationale for early treatment of MS with IFN-b1a, and managing side effects of IFN-b1a in patients. Dr. Munschauer lectures nationally and internationally on the use of IFN-b1a in patients with MS and is considered one of the leaders in the field of MS treatment.

Shirley O'Leary, RN, MSCN, practices with J. Theodore Phillips, MD, at the Multiple Sclerosis Center at Texas Neurology. Over the last 10 years she has been involved in all aspects of patient care, including MS research. She is a member of the International Organization of MS Nurses and the American Association of Neuroscience Nurses and has collaborated on several published MS articles.

Mariko Kita, MD
Virginia Mason Medical Center, Seattle

Dr. Kita attended medical school at the Northwestern University School of Medicine, her residency in neurology at the Hospital of the University of Pennsylvania, internship in internal medicine at Northwestern Memorial Hospital, and a fellowship in neuroimmunology at Mt. Zion Multiple Sclerosis Center, University of California School of Medicine.

Dr. Kita is currently Director of the Virginia Mason Multiple Sclerosis Center and is board certified by the American Board of Psychiatry and Neurology.

Faculty Disclosures

Full Disclosure Policy Affecting CME/CE Activities
As providers accredited by the Accreditation Council for Continuing Medical Education (ACCME) and American Nursing Credentialing Center, it is the policy of the Johns Hopkins University School of Medicine and the Institute of Johns Hopkins Nursing to require the disclosure of the existence of any significant financial interest or any other relationship a faculty member or a provider has with the manufacturer(s) of any commercial product(s) discussed in an education presentation. This is also the policy of the University of Tennessee College of Pharmacy. The presenting faculty reported the following:

Dr. Douglas Kerr has received grant and research support from the NIH.

Dr. Frederick E. Munschauer has received grants and research support from Biogen Idec, Bristol-Myers Squibb, Pfizer, Merck, AstraZeneca, Sanofi, National Institute of Health, and the IHA Foundation. He has served as a consultant for Biogen Idec and has received honorarium from Biogen Idec, Sanofi-Synthelabo, and Pfizer.

Julie Farace, RN, BSN has no relationships to disclose.

Dr. J. Theodore Phillips has received honorarium from Biogen Idec, Ilex, Neurocrine Biosciences, and Serono

Dr. Mariko Kita has received grants and research support from Serono, Biogen Idec, Teva Neuroscience. She has served as a consultant for Serono, Biogen Idec, Teva Neuroscience, and Berlex.

Shirley O'Leary, RN, MSCN has received honorarium from Biogen Idec.

Off-Label Discussion


NOTICE: In accordance with the ACCME and ANCC Standards for Commercial Support, the audience is advised that one or more presentations in this continuing medical education activity does contain references to unlabeled or unapproved uses of drugs or devices. The following faculty members have disclosed that their presentation will reference unlabelled/unapproved use of drugs or products:
J. Theodore Phillips, MD, PhD
Shirley O'Leary, RN, MSCN
Julie Farace, RN, BSN
Frederick E. Munschauer, MD
Mariko Kita, MD

Rituxan (rituximab), Zenapax (daclizumab), Campath (alemtuzumab), combination (natalizumab and Rebif [interferon beta 1-a]), combination (natalizumab and Betaseron [interferon beta-1b]), combination (natalizumab and mitoxantrone), combination (natalizumab and Copaxone [glatiramer acetate])

This educational program is supported through an educational grant from Biogen Idec and Elan Pharmaceuticals.

© 2005 The Johns Hopkins University School of Medicine, The Institute of Johns Hopkins Nursing and The University of Tennessee College of Pharmacy. All rights reserved.

Launch Presentation

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