Advances in MS
Module 1
Early Diagnosis of
Multiple Sclerosis
Module 2
Management of Side Effects of Treatments for Multiple Sclerosis
Module 3
Neutralizing Antibodies to Interferon Beta in the Treatment of Multiple Sclerosis
Module 4
Brain and Spinal Cord Atrophy

For more MS programs visit MSLeaders.org, which is not associated with Johns Hopkins

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CME Information
Faculty
Faculty Disclosures
Off-Label Discussion
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Management of Side Effects of Treatments for Multiple Sclerosis
Sponsored by The Johns Hopkins University School of Medicine

Program Overview
Disease-modifying therapies (interferon, glatiramer and mitoxantrone) are the mainstay in the treatment of multiple sclerosis (MS). Patients may develop side effects, however, that need to be treated aggressively to ensure that they derive maximum benefit from these medications through compliance and persistency.

Target Audience
Neurologists and other healthcare professionals involved in the management and treatment of patients with MS. There are no prerequisites for this program.

Educational Objectives
At the conclusion of this activity, participants should be better able to:

  • Describe the most frequent side effects of disease-modifying therapies
  • Understand management of injection-site reactions and post-injection reactions
  • Understand the importance of managing adverse reactions, so patients take their medications as directed and stay on them
  • Integrate other healthcare professionals into side effect vigilance efforts

Disclaimer
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of The Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

CME Information

Accreditation
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation
The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 1 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

Date of Release and Expiration
This course was released on September 15, 2004 and will expire on September 15, 2005. CME credit cannot be awarded after this date. Estimated time to complete this educational activity: 1 hour.

Statement of Responsibility
The Johns Hopkins University School of Medicine takes responsibility for the content, quality and scientific integrity of this CME activity.

Privacy Statement
The Office of Continuing Medical Education (CME) at The Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. Johns Hopkins University School of Medicine CME maintains its Internet site as an information resource and service for physicians, other health professionals and the public. Continuing Medical Education at The Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet-based program. Your information will never be given to anyone outside of The Johns Hopkins University School of Medicine's CME program. Continuing Medical Education collects only the information necessary to provide you with the services that you request.

Copyright 2004, The Johns Hopkins University School of Medicine. All rights reserved.

Faculty

Peter Calabresi, MD (Program Chair)
Associate Professor of Neurology
The Johns Hopkins University School of Medicine
Director
The Johns Hopkins Multiple Sclerosis (MS) Center

Dr. Calabresi is an associate professor of neurology and director of The Johns Hopkins Multiple Sclerosis (MS) Center. He specializes in the diagnosis and management of MS. As director of the MS clinic, Dr. Calabresi is the principal investigator on several clinical trials and also oversees translational laboratory research projects. Dr. Calabresi has designed and directed several clinical trials investigating combination drug therapies in MS. He is on the advisory board for 3 national multicenter clinical trials. Dr. Calabresi's specific laboratory research interest lies in understanding the mechanisms of T lymphocyte migration into the brain and spinal cord. He has published numerous articles on the adhesion molecules and chemokine receptors responsible for T cell homing to the brain in MS. He recently reported on a novel potassium channel, Kv1.3, which is specifically and highly expressed on chronically activated immune cells in the blood and brains of people with MS. The availability of Kv1.3 blocking drugs makes this an attractive future therapeutic target in MS. Dr. Calabresi was also recently awarded a 5-year collaborative MS center grant from the National Multiple Sclerosis Society to study mechanisms of neurodegeneration and strategies for neuroprotection in MS.

Steven L. Galetta, MD
Professor of Neurology
University of Pennsylvania

Dr. Galetta is currently the Van Meter Professor of Neurology and a member of the multiple sclerosis division at the University of Pennsylvania School of Medicine. He is also the director of the neuro-opthamology division and the neurology-training program. After earning his bachelor's degree from the University of Pennsylvania and his medical degree from the Cornell University Medical College, Dr. Galetta returned to Philadelphia where he completed his residency in neurology at the Hospital of the University of Pennsylvania. He then went on to complete a fellowship in neuro-ophthalmology at the Bascom Palmer Eye Institute in Miami, Florida. Dr. Galetta is board certified in neurology and neuro-ophthalmology. Dr. Galetta is published in several top medical journals and has been named one of the "Best Doctors in America" on numerous occasions. He is a member of the American Neurologic Association, the American Academy of Neurology, the Stroke Council, the Frank B. Walsh Society and the North American Neuro-Ophthalmology Society.

Mitchell Freedman, MD
Associate Professor of Neurology
University of North Carolina

Dr. Freedman earned his undergraduate degree in psychology at Haverford College and his medical degree at the University of Pennsylvania. He completed his internship and residency training at Duke University Medical Center. He is an associate clinical professor of neurology at the University of North Carolina and is a fellow of the American Academy of Neurology. He is the codirector of the Triangle Multiple Sclerosis Center and is a cofounder of Raleigh Neurology Associates.

Dusan Stefoski, MD
Associate Professor of Neurology
Rush University Medical Center

Dr. Stefoski, a board-certified neurologist since 1980, is an associate professor of neurology at the Rush University Medical College, a senior attending neurologist at the Rush-Presbyterian-St. Luke's Medical Center and the director of the Rush Multiple Sclerosis Center in Chicago.

Dr. Stefoski received his medical degree and concluded an internship at the University of Zagreb Medical School in Croatia (formerly Yugoslavia). He completed his neurology residency at Rush and his training in neuropathology at Stanford University. Dr. Stefoski, a fellow of the American Academy of Neurology, has been doing novel research in the field of MS at Rush and has been participating in collaborative projects with researchers in the United States and internationally.

In association with Dr. Floyd Davis, he pioneered the proof-of-concept and efficacy of
4-aminopyridine in MS. He teaches and lectures nationally and internationally.

Faculty Disclosures

Full Disclosure Policy Affecting CME Activities
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of The Johns Hopkins University School of Medicine to require the disclosure of the existence of any significant financial interest or any other relationship a faculty member or a sponsor has with the manufacturer(s) of any commercial product(s) discussed in an educational presentation. The presenting faculty reported the following:

Dr. Steven Galetta has been paid as a consultant to Biogen Idec and has received grant and research support, as well as honoraria from Biogen Idec.

Dr. Peter Calabresi has received grant and research support and served as a consultant with Biogen Idec, Berlex, Inc., Teva Neuroscience, Inc. and Serono, Inc.

Dr. Mitch Freedman has received honoraria from Biogen Idec, Janssen Pharmaceutica Products, Glaxo SmithKline and Pfizer Inc.

Dr. Dusan Stefoski has received grant and research support as well as consulting fees from Biogen Idec, and has received honoraria from Biogen Idec, Berlex, Inc., Serono and Teva Pharmaceuticals.

Off-Label Discussion

No faculty member has indicated that their presentation will include information on off-label products.

This educational program is supported through an educational grant from Biogen Idec.
Copyright 2004, The Johns Hopkins University School of Medicine. All rights reserved.

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