
The reporting of progressive multifocal leukoencephalopathy (PML) in association with natalizumab therapy, leading to the temporary withdrawal from the market of this agent, makes education regarding this relatively unusual disease critical. This program will outline the current state of knowledge of PML and discuss the disease itself (both the primary disease and the phenomenon occurring secondary to reversible causes). The clinical manifestations of PML vs. MS, the association of PML with natalizumab and other immune modulators/suppressants, and the fact that there is no current treatment—save immune restoration—will also be covered.
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